and Zelboraf is being developed in collaboration with Plexxikon, Inc. A Phase I clinical trial evaluating GDC-0973 as a single agent in solid tumor is ongoing.GDC-0973 is being developed in collaboration with Exelixis, Inc. Receptor tyrosine kinase signaling, mitogen-activated protein kinase (MEK) selective inhibitor StatusĪ Phase III and a Phase Ib clinical trial in combination with Zelboraf® (vemurafenib) for metastatic melanoma a Phase Ib clinical trial in combination with GDC-0068, an Akt Inhibitor, for solid tumors and a Phase Ib clinical trial in combination with GDC-0941, a PI3 Kinase Inhibitor, for solid tumors are ongoing. Inappropriate activation of the MEK/ERK pathway promotes cell growth in the absence of exogenous growth factors.

Video: Personalized Learning Vs.GDC-0973 (RG7421), a selective inhibitor of MEK, also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.

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meaningful engagementġ5:30 - What thinking does the student have to do?ġ9:00 - Lessons from Game Developers Conference You can listen to the episode in the player below: Topics Covered in the Podcast:ģ:00 - Game Developers Conference and what sets it apartĥ:15 - Educational games' place in the industryħ:30 - Gamification vs. He and Brian then talk about some of the ways educators and administrators can ascertain whether an educational product is offering a true game-based learning experience, as opposed to a superficial layer of gamification. Ki shares some of his experience from this year’s Game Developers Conference, and the unique and often challenging place that educational games hold in the industry. In our latest episode, Brian welcomes Director of ST Math Content Ki Karou to the show for a discussion on game design, student engagement and more. In each episode of the Inside Our MIND podcast, we take a look at issues and challenges facing education that we are working to address through research, technology and strategic initiatives.

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